As psilocybin-assisted healing becomes more accessible, one question comes up again and again: Can I take psilocybin if I’m on antidepressants like SSRIs? The short answer is: yes, you can. But it may affect how psilocybin works—and it may also raise deeper questions about what kind of healing you’re after.

In this post, we’ll explore how SSRIs and psilocybin interact, what the research says, and why some people are beginning to explore psychedelics as an alternative to long-term pharmaceutical treatment.

In the last few years, there’s been a quiet but powerful shift in how the medical world views psilocybin—the active compound found in certain psychedelic mushrooms. Once misunderstood or stigmatized, this naturally occurring substance is now being recognized for its potential to support healing, especially in people living with depression. In fact, the U.S. Food & Drug Administration (FDA) has granted Breakthrough Therapy Designation to multiple psilocybin-based treatments. But what does that actually mean? And why does it matter?